After submitting key term, narrow your results by filtering by clinical topic or selecting specific document types. How Can We Do Better? 2018 American College of Cardiology Foundation. The American College of Cardiology, a 49,000-member nonprofit medical society, is dedicated to enhancing the lives of acc aha cholesterol guidelines 2016 pdf patients through continuous quality improvement, patient-centered care, payment innovation and professionalism.
Access the ACC’s trusted knowledge base of Guidelines and Clinical Documents. Registration and housing for ACC. Register early to SAVE and get your first choice of hotels! Looking for content tailored to your interests? Martin, Hans-Rudolf Berthoud and Steven B.
In the United States as of 2015 the 10 mg pill costs between 4. These guidelines recommend increasing the statin dose in certain populations, but do not recognize target serum cholesterol levels or recommend the use of non-statin cholesterol lowering drugs. LDL goals using statins alone. The question of whether ezetimibe could make a difference in major outcomes was examined in the IMPROVE-IT trial, which compared treatment with ezetimibe vs. The absolute bioavailability cannot be determined, since ezetimibe is insoluble in aqueous media suitable for injection.
Ezetimibe is primarily metabolized in the liver and the small intestine via glucuronide conjugation with subsequent renal and biliary excretion. Both the parent compound and its active metabolite are eliminated from plasma with a half-life around 22 hours, allowing for once-daily dosing. 7-fold, 3-to-4-fold, and 5-to-6-fold, respectively, compared to healthy subjects. Stone NJ, Robinson JG, Lichtenstein AH, et al.
American Heart Association Task Force on Practice Guidelines”. Catapano AL, Reiner Z, De Backer G, et al. Teramoto T, Sasaki J, Ishibashi S, et al. An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia–full report”. National Library of Medicine, National Institutes of Health, U. Department of Health and Human Services. Mechanism of Drug-Drug Interactions Between Warfarin and Statins”.