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HSR experiments were recorded during vaccination trials in the 1700s. In these early trials, physicians used themselves or their slaves as test subjects. Experiments on others were often conducted without informing the subjects of dangers associated with such experiments”. 1906 there were no regulations or concerns with regard to research ethics on humans. 1946, was the first law which stated that researchers must have consent from their human subjects.
This was due in whole to the killings of numerous individuals within Nazi concentration camps. The Nazi physicians performed brutal medical experiments upon helpless concentration camp inmates. The basis of the Nuremberg Code is that the benefits of the research must outweigh the risks. Research has been conducted unethically in other experiments, not in regard to torture but in cases of consent, deception, privacy, and confidentiality.